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Symbol
Name
ID 		Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
MGI:98354
Phenotype annotations related to cardiovascular system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Bruising susceptibility
Abnormal cardiovascular system morphology
Unroofed coronary sinus
Atrial septal defect
Primum atrial septal defect
Secundum atrial septal defect
Sinus venosus atrial septal defect
Ventricular septal defect
Right ventricular dilatation
Abnormal pulmonary valve morphology
Hypertrophic cardiomyopathy
Cardiomegaly
Coarctation of aorta
Pulmonary artery stenosis
Patent ductus arteriosus
Stroke
Systolic heart murmur
Pulmonic stenosis
Pulmonary arterial hypertension
Abnormal EKG
Right axis deviation
Arrhythmia
Palpitations
Atrial fibrillation
Atrial flutter
Right bundle branch block
Congestive heart failure
Abnormality of the lymphatic system
Abnormality of the spleen
Disease(s) Associated with SOS1
atrial heart septal defect
Noonan syndrome
Noonan syndrome 4
pulmonary valve stenosis

Mouse Phenotypes
cardiovascular system phenotype
abnormal cardiovascular system morphology
abnormal blood vessel morphology
blood vessel congestion
abnormal myocardial fiber morphology
increased myocardial fiber size
myocardial fiber degeneration
abnormal myocardial trabeculae morphology
heart left ventricle hypertrophy
heart right ventricle hypertrophy
abnormal heart morphology
abnormal heart atrium morphology
ostium secundum atrial septal defect
abnormal heart position or orientation
thick interventricular septum
ventricular septal defect
enlarged heart
thick aortic valve cusps
aortic valve stenosis
abnormal heart ventricle morphology
abnormal heart left ventricle morphology
distended pericardium
enlarged pericardium
pericardial effusion
cardiac fibrosis
cardiac interstitial fibrosis
abnormal cardiovascular system physiology
hemorrhage
abnormal fetal cardiomyocyte proliferation
increased cardiomyocyte apoptosis
Availability Mouse Genotype
Sos1tm1.2Rak/Sos1tm1.2Rak
Sos1tm1Dlb/Sos1tm1Dlb !
Sos1tm1.2Rak/Sos1+ *
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory